MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis
نویسندگان
چکیده
منابع مشابه
Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function
Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus cancer cells tend to be more sensitive to proteasome inhibition. However, this approach has been limited in some cases by toxicity to normal ce...
متن کاملNeuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis
During neurodegenerative disease, the toxic accumulation of aggregates and misfolded proteins is often accompanied with widespread changes in peripheral metabolism, even in cells in which the aggregating protein is not present. The mechanism by which the central nervous system elicits a distal reaction to proteotoxic stress remains unknown. We hypothesized that the endocrine communication of ne...
متن کاملFailed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins
Modification by the ubiquitin-like protein SUMO affects hundreds of cellular substrate proteins and regulates a wide variety of physiological processes. While the SUMO system appears to predominantly target nuclear proteins and, to a lesser extent, cytosolic proteins, hardly anything is known about the SUMOylation of proteins targeted to membrane-enclosed organelles. Here, we identify a large s...
متن کاملA Meticulous Analysis of Mergesort Programs
Abst rac t . The efficiency of mergesort programs is analysed under a simple unit-cost model. In our analysis the time performance of the sorting programs includes the costs of key comparisons, element moves and address calculations. The goal is to establish the best possible time-bound relative to the model when sorting n integers. By the well-known information-theoretic argument n log 2 n O(n...
متن کاملAutoimmune lymphoproliferative syndrome: meticulous care for diagnosis.
Autoimmune lymphoproliferative syndrome (ALPS) is a prototypic disorder of abnormal lymphocyte homeostasis. In the September 2005 issue of The Iranian Journal of Allergy, Asthma and Immunology, a patient with clinical features consistent with ALPS was described. Although the clinical presentation was in favor of ALPS, a precise diagnosis needed more laboratory evaluations.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2018
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2018.06.027